Current Clinical Trials at Ballad Health
Groundbreaking research close to home
Ballad Health has brought together a team of innovative physicians and clinicians who are at the forefront of leading-edge research and clinical trials.
We're a consistent leader in clinical research, and we're leveraging that track record to better improve healthcare across the region.
View Ballad Health's current clinical trials
What are clinical trials?
Clinical trials can be defined in a number of ways, but they typically involve studies to evaluate the effectiveness of new drugs and treatments.
The data from these trials helps us understand what approach will work best for all Ballad Health patients moving forward.
Benefits of clinical trial participation
Research and trials often lead to new approaches in diagnosing, preventing and treating conditions ranging from heart disease to cancer. This is especially important in fields such as cardiology, oncology and hematology.
Our team is driven to ensure our communities across the region have access to advanced treatment options. In the past, many people in the Appalachian Highlands community had to travel to large teaching hospitals for the latest in drugs and tech. By extending studies to our community, patients now have a choice of staying closer to home when joining a clinical trial.
Participants in local clinical trials can typically play a more active role in their own healthcare, gaining access to new research and treatments before they're available – leaving a legacy that benefits all future patients.
Consider your trial options early
You should work with your doctor to decide as early in your evaluation as possible whether participating in a clinical trial is an appropriate treatment option for you. Once other treatments begin, you may become ineligible to participate in some clinical trials.
Your safety and privacy are our top priority
To ensure safety for all our patients, every study is reviewed and approved by an Institutional Review Board, the director of research and a clinical research committee.
Our patients are monitored carefully throughout every clinical trial. Special care is always taken to help you understand any study that you participate in so you can be an active participant in your own treatment.
All patient information regarding clinical trials is kept confidential.
How to participate in a clinical trial
If you're approached about participating in a trial or have expressed interest in joining a trial, listen carefully and always discuss it with your family and doctor.
Volunteering for any study is a choice only you can make.
If you're interested in possible trials or research studies, you can speak to your physician or contact our research team for more details and information at clinicaltrials@balladhealth.org or by calling (423) 230-5615.
Current active clinical trials at Ballad Health
Click on your preferred specialty to see the list of active or ongoing trials offered at Ballad Health facilities.
Evaluation in STEMI Patients Using FDY-5301 (IOCYTE AMI-3)
Locations: Ballad Health CVA Heart Institute (Johnson City), Johnson City Medical Center
Principal investigator (PI): Jack Whitaker, MD
Location: Holston Valley Medical Center
Post-Approval Study of the TREO Abdominal Stent-Graft System (TREO PAS)
Locations: CVA Heart Institute (Kingsport, Johnson City)
Principal investigators (PIs): Robert Allen, MD (Kingsport); Richard Yoon, MD (Johnson City)
Locations: Holston Valley Medical Center
Location: Greeneville Community Hospital
Principal investigator (PI): Jack Whitaker, MD
Location: Holston Valley Medical Center
Location: Greeneville Community Hospital
Principal investigator (PI): Jack Whitaker, MD
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)
Location: Holston Valley Medical Center
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting (C-Guardians)
Location: Holston Valley Medical Center
Location: Holston Valley Medical Center
Cepheid AML NPM1 Mutation Test
The purpose of this collection is for the acquisition of EDTA peripheral blood (PB) specimens from patients who (i) have been diagnosed with NPM1-mutated AML and (ii) are being monitored for NPM1 mutation. Consists of 3 visits.
Location: Regional Cancer Center (Johnson City)
Principal investigator (PI): Devapiran Jaishankar, MD
SeraTrials
Consists of a single clinical research sample collection. Cord blood and cancer targeted samples will change periodically based on sponsor’s need.
Locations: Indian Path Community Hospital, Bristol Regional Medical Center, Regional Cancer Center (Johnson City), Johnson City Medical Center, Franklin Woods Community Hospital, Sycamore Shoals Hospital
Principal investigator (PI): Matthew Loos, MD
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Location: Ballad Health Cancer Center (Kingsport)
Principal investigators (PIs): Scott Coen, MD; Paul Kramer, MD
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Johnson City Medical Center
Principal investigator (PI): Kyle Colvett, MD
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer (MRD)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Enhancing Cancer Care of Rural Dwellers Through Telehealth and Engagement (ENCORE)
Available for newly diagnosed or relapsed patients. Requires access to reliable video capable device with internet. A device and/or data plan can be provided to patients who need it.
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
Location: Ballad Health Cancer Center (Kingsport)
Principal investigators (PIs): Paul Kramer, MD; Jamal Maatouk, MD; Ibrahim Nakkoul, MD; Yonette Paul, MD; Asheesh Shipstone, MD; Marco Da Silva, MD
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Norton)
Principal investigators (PIs): Scott Coen, MD (Kingsport); Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
Locations: Ballad Health Cancer Center (Kingsport, Bristol, Norton)
Principal investigators (PIs): Paul Kramer, MD (Kingsport); Jamal Maatouk, MD (Kingsport); Harish Madala, MD (Norton); Tamara Musgrave, MD (Bristol); Ibrahim Nakkoul, MD (Kingsport); Yonette Paul, MD (Kingsport); Ryan Shao, MD (Bristol); Asheesh Shipstone, MD (Kingsport); Marco Da Silva, MD (Kingsport)
AngioSafe Peripheral CTO Crossing System Study (RESTOR-1 Study) (RESTOR-1)
Location: Holston Valley Medical Center
LIFE-BTK Randomized Controlled Trial (LIFE-BTK)
Location: Holston Valley Medical Center
Location: Holston Valley Medical Center
BOLT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
Location: Holston Valley Medical Center
JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization (JAGUAR)
Location: Holston Valley Medical Center
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial) (ReMEDy2)
Location: Johnson City Medical Center
Principal investigator (PI): Tanzid Shams, MD
Location: Johnson City Medical Center
Principal investigators (PIs): Bracken Burns, MD; Christy Lawson, MD
Contact us
If you have questions about any of our active trials, you can reach out to us by emailing clinicaltrials@balladhealth.org or calling (423) 230-5615.